Titlebook: Innovations for Next-Generation Antibody-Drug Conjugates; Marc Damelin Book 2018 Springer International Publishing AG, part of Springer Na

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Introduction: Motivations for Next-Generation ADCs,innovations of next-generation ADCs described throughout the volume. A framework for designing and interpreting preclinical pharmacology studies is proposed such that emerging technologies can be rigorously evaluated and molecules can be judiciously optimized.

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Targeting Drug Conjugates to the Tumor Microenvironment: Probody Drug Conjugates,making antibody prodrugs that have been or could be used to selectively deliver drug to a tumor compared to normal tissues. These technologies have the potential to lower on-target, off-tumor toxicities and enable better efficacy of ADCs due to better target selection and the delivery of higher concentrations of drug to tumors.