Titlebook: Innovations for Next-Generation Antibody-Drug Conjugates; Marc Damelin Book 2018 Springer International Publishing AG, part of Springer Na

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Combining ADCs with Immuno-Oncology Agents,nogenic cell death (ICD), which leads to potent stimulation of effector T-cell activation as well as their recruitment into tumors. It has been recently demonstrated that some ADC payloads are also able to elicit ICD. Furthermore, several cytotoxic warheads used in ADCs can directly induce dendritic

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Utility of PK-PD Modeling and Simulation to Improve Decision Making for Antibody-Drug Conjugate Devssful application of this tool can not only enhance the scientific understanding of the processes underlying PK-PD of ADCs but can also provide comprehensive model-derived outcomes that can help accelerate the decision-making process. Within this book chapter, we have discussed an array of different

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HER2-Targeted ADCs: At the Forefront of ADC Technology Development,different drug linkers, drug to antibody ratios, site-specific antibody drug conjugates, and biparatopic antibody drug conjugates. Anti-HER2 antibody drug conjugates currently in clinical testing are described. Promising early clinical data are emerging from some of the ADCs employing novel technolo

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Next Horizons: ADCs Beyond Oncology, account for designing ADCs for non-oncology indications, including payload and antibody selection. With the evolution of ADC platform and technology, more ADCs for non-oncology indications are yet to be developed.

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and biomechanics as well as the pathophysiologyleading to various cervical degenerative disorders and the possible neurological sequelae.  Subsequent chapters outline characteristics of the clinical presentation and the various diagnostic modalities to evaluate these patients.  Key elements involved

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Frank Comer,Changshou Gao,Steve Coatsspace and promoted a localized IA effect. Subretinal IA dissolved in BSS caused less severe and less consistent PR degeneration. Healon® or BSS alone did not induce PR damage. Thus, a model with PR-lacking area centralis has been created by subretinal injection of IA with a viscous solution. This mo

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Jack Lin,Jason Sagerts of novel polymers with inherent environmentally favorable properties such as renewability and degradability and a series of interesting monomers found in the metabolisms and cycles of nature are given.978-3-642-07597-1978-3-540-45734-3Series ISSN 0065-3195 Series E-ISSN 1436-5030