| 书目名称 | Innovations for Next-Generation Antibody-Drug Conjugates |
| 编辑 | Marc Damelin |
| 视频video | http://file.papertrans.cn/468/467020/467020.mp4 |
| 概述 | Focus on next-generation ADCs for oncology and other diseases.Description & analysis of current technological innovations for ADCs.ADC clinical development in the context of immuno-oncology |
| 丛书名称 | Cancer Drug Discovery and Development |
| 图书封面 |  |
| 描述 | . .Antibody-drug conjugates (ADCs) stand at the verge of a transformation. Scores of clinical programs have yielded only a few regulatory approvals, but a wave of technological innovation now empowers us to overcome past technical challenges. This volume focuses on the next generation of ADCs and the innovations that will enable them. The book inspires the future by integrating the field’s history with novel strategies and cutting-edge technologies. While the book primarily addresses ADCs for solid tumors, the last chapter explores the emerging interest in using ADCs to treat other diseases.. The therapeutic rationale of ADCs is strong: to direct small molecules to the desired site of action (and away from normal tissues) by conjugation to antibodies or other targeting moieties. However, the combination of small and large molecules imposes deep complexity to lead optimization, pharmacokinetics, toxicology, analytics and manufacturing. The field has made significant advances in all of these areas by improving target selection, ADC design, manufacturing methods and clinical strategies. These innovations will inspire and educate scientists who are designing next-generation ADCs |
| 出版日期 | Book 2018 |
| 关键词 | Antibody-Drug Conjugates; pharmacokinetics,; oncology; immuno-oncology; Conjugation |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-3-319-78154-9 |
| isbn_softcover | 978-3-030-08627-5 |
| isbn_ebook | 978-3-319-78154-9Series ISSN 2196-9906 Series E-ISSN 2196-9914 |
| issn_series | 2196-9906 |
| copyright | Springer International Publishing AG, part of Springer Nature 2018 |
|Archiver|手机版|小黑屋|
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