Titlebook: Inhibitory Regulation of Excitatory Neurotransmission; Mark G. Darlison Book 2008 Springer-Verlag Berlin Heidelberg 2008 G-Protein Coupled

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Modulation of Excitation by Metabotropic Glutamate Receptors,e localized outside the immediate vicinityof transmitter release sites, thereby setting specific requirements for their activation, such as cooperationbetween synapses, burst activity, and glial involvement in the regulation of ambient glutamate levels.

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0080-1844 ), glycine receptors, GABA transporters and potassium channels. In addition, the consequences of mutations that disrupt the regulation of excitatory neurotransmission, and efforts to target the GABAergic system for therapeutic benefit, are discussed..978-3-642-09162-9978-3-540-72602-9Series ISSN 0080-1844 Series E-ISSN 1861-0412

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Regulation of Excitation by GABAA Receptor Internalization,er factors that guide insertionat synaptic or perisynaptic/extrasynaptic sites, where phasic and tonic inhibition are mediated, respectively.Once at the cell surface, the receptor is laterally mobile and subject to both constitutive and regulatedendocytosis. Following endocytosis the receptor underg

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Regulation of Excitability by Extrasynaptic GABAA Receptors,tal, physiological and pathological regulation of GABA uptake andGABA. receptor expression. There is also growing evidence that tonic currents playan important role in epilepsy, sleep (also actions of anaesthetics and sedatives), memory and cognition. Therefore, drugs specifically aimed at targeting

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Regulation of Excitation by GABA Neurotransmission: Focus on Metabolism and Transport,rs or GABA-T are capable of regulating the inhibitorytonus thus controlling excitation. This has led to development of clinically efficatious antiepilepticdrugs. This paper shall review recent progress in targeting these pharmacological entities.

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Book 2008s (specifically, GABA.B. receptors, metabotropic glutamate receptors and neuropeptide receptors), glycine receptors, GABA transporters and potassium channels. In addition, the consequences of mutations that disrupt the regulation of excitatory neurotransmission, and efforts to target the GABAergic system for therapeutic benefit, are discussed..

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Nancy J. Leidenheimeretence-based view“, also der Kompetenzbasierten Unternehmensstrategie verstanden werden kann. Innerhalb dieser Lesart war es vor allem das „competence-based management“ im Sinne von Hamel und Prahalad, das die Bedeutung interner organisatorischer Aufstellung in hinreichender Form berücksichtigt. Spi