| 书目名称 | Inhibitory Regulation of Excitatory Neurotransmission | | 编辑 | Mark G. Darlison | | 视频video | | | 概述 | First book to look not exclusively at GABA receptors for the regulation of excitatory neurotransmission, but at all different types of inhibitory proteins.Written by experts from around the world | | 丛书名称 | Results and Problems in Cell Differentiation | | 图书封面 |  | | 描述 | .Within the central and peripheral nervous systems of animals, including man, inhibition is crucial to counterbalance excitatory neurotransmission, which is predominantly mediated by glutamate and its receptors. Although, particularly in brain, much of this inhibition is provided by classical post-synaptic GABA.A. receptors, many other proteins and mechanisms regulate excitation. These exist both to "fine tune" neurotransmission and to prevent overexcitation that could lead to conditions such as epilepsy and excitotoxicity, which can result in cell death. This book reviews aspects of GABA.A. receptor function, as well as the properties of a variety of other important inhibitory proteins, such as GABA.C. receptors, G-protein coupled receptors (specifically, GABA.B. receptors, metabotropic glutamate receptors and neuropeptide receptors), glycine receptors, GABA transporters and potassium channels. In addition, the consequences of mutations that disrupt the regulation of excitatory neurotransmission, and efforts to target the GABAergic system for therapeutic benefit, are discussed.. | | 出版日期 | Book 2008 | | 关键词 | G-Protein Coupled Receptor; Glutamat; Ion-Channel Receptor; Nervous System; Neuronal Inhibition; Neurotra | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-540-72602-9 | | isbn_softcover | 978-3-642-09162-9 | | isbn_ebook | 978-3-540-72602-9Series ISSN 0080-1844 Series E-ISSN 1861-0412 | | issn_series | 0080-1844 | | copyright | Springer-Verlag Berlin Heidelberg 2008 |
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发表于 2025-3-21 17:47:42
