Titlebook: Inhibition of Folate Metabolism in Chemotherapy; The Origins and Uses George H. Hitchings Book 1983 Springer-Verlag Berlin Heidelberg 1983

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Selective Inhibitors of Bacterial Dihydrofolate Reductase: Structure-Activity Relationshipssulfamethoxazole as a broad spectrum antibacterial agent, it still stands almost alone in this field as a species-specific dihydrofolate reductase (DHFR) inhibitor. It was preceded by its close relative diaveridine (2) (F. et al. 1951 a; H. 1955), which found its utility as an anticoccidial agent, a

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Kinetics of Antibacterial Effects Eusaprim, and Bactrim, consisting of trimethoprim, 2,4-diamino-5-(3′,4′,5′-trimethoxybenzyl)pyrimidine (TMP) and a sulfonamide, sulfamethoxazole (SMX). Many of these studies have been concerned with the mode of action, sensitivity testing procedures, or the development of resistance (H. and B. 1965

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Clinical Pharmacokinetics of Co-trimoxazolee steps in the normal bacterial metabolism of folinic acid. All sulfonamides competitively inhibit the utilization of p-aminobenzoic acid (pABA) in the synthesis of dihydrofolic acid. Since humans do not synthesize dihydrofolic acid but depend on dietary sources for their needs, this inhibition occu

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Trimethoprim Alone: Clinical Useshancement of TMP’s activity by sulfamethoxazole and have more recently been fascinated by its synergism with other sulfonamides as well as agents as disparate as polymyxin and rifampin, it would be unfortunate if this intellectual attraction were to prevent a critical examination of the potential us