| 书目名称 | Inflammatory Mechanisms in Mediating Hearing Loss | | 编辑 | Vickram Ramkumar,Leonard P. Rybak | | 视频video | http://file.papertrans.cn/465/464727/464727.mp4 | | 概述 | Details several different aspects of the cochlear inflammatory process.Discusses recent clinical trials focusing on the use of anti-inflammatory agents for the treatment of drug, noise-induced and aut | | 图书封面 |  | | 描述 | . Common forms of preventable hearing loss are drug and noise-induced hearing loss which are believed to be produced by a similar mechanism. The generation of reactive oxygen species appears to be a common mechanism mediating hearing loss produced by these different sources. As such, a number of laboratories have focused their research towards identifying the sources of ROS production in the cochlea following administration of chemotherapeutic agents or noise exposure. This led to the identification of ROS generating enzymes, such as xanthine oxidases, nitric oxide synthase, and NADPH oxidases which are activated and/or induced during the development of hearing loss. A consequence of these findings was the implementation of antioxidants in preclinical studies for the treatment of hearing loss. These antioxidants have provided different levels of protection in animal and human studies, but none of these have been approved by the US Food and Drug Administration for the treatmentof hearing loss.. More recently, it was shown that noise-induced hearing loss was associated with recruitment of inflammatory cells and mediators in the cochlea. This finding would suggest that noise could pr | | 出版日期 | Book 2018 | | 关键词 | cochlear function; oxidative stress; lipid mediators; therapy; anti-inflammatory drugs | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-319-92507-3 | | isbn_softcover | 978-3-030-06447-1 | | isbn_ebook | 978-3-319-92507-3 | | copyright | Springer International Publishing AG, part of Springer Nature 2018 |
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