Titlebook: Inflammation and Metastasis; Yoshiro Maru Book 2016 Springer Japan 2016 Inflammation.Metastasis.Leukocytes.Microenvironment.Pathogen senso

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Reinforces understanding of inflammation with full step-by-s.This book provides the latest information on cancer metastasis from the standpoint of inflammation, especially innate immune reactions caused by endogenous mediators but not exogenous pathogens, with ideas on how to understand the complica

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Premetastatic Microenvironmentple, skilled surgeons can remove a tumor with minimal tissue damage as represented by little blood loss during operation. Earlier removal of the primary tumor is better for cure, because it might be before the regrowth of the metastasizing tumor cells. Once they begin regrowth, the situation is similar to that in the primary tumor.

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Extension of Endogenous FieldConversion between self and non-self can affect the field size for each. There are several ways by which the conversion is achieved.

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Evidence for Existence of Endogenous TLR4 LigandsBefore focusing on the discussion of the endogenous ligands of TLR4—accurately speaking the TLR4/MD-2 complex—we are absolutely in need of the knowledge of its authentic ligand, LPS. In human-circulating LPS in serum is detected in physiological conditions in the range of 150–350 pg/ml.

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Tumor MicroenvironmentHere I discuss the assumption that tumor cells exist first in the context of host or stromal cells within the restricted tumor tissue.

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https://doi.org/10.1007/978-4-431-56024-1Inflammation; Metastasis; Leukocytes; Microenvironment; Pathogen sensors; Immune system; Coagulation; Angio

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Yoshiro MaruOffers new concepts of inflammation such as homeostatic inflammation, which helps to give new insights into the understanding of metastasis.Reinforces understanding of inflammation with full step-by-s