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Titlebook: Inbred Strains in Biomedical Research; Michael F. W. Festing Textbook 1979Latest edition Michael F. W. Festing 1979 boundary element metho

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楼主: miserly
发表于 2025-3-27 00:41:53 | 显示全部楼层
Nomenclature often changed, leading eventually to extreme confusion. It is regrettable that in species other than the mouse, where no committee on standardised nomenclature has jurisdiction, similar confusion still occurs.
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Genetic Quality Control and second to continue to demonstrate that, through mutation, miscegenation or any other cause, they have not ceased to be correctly designated. A programme of genetic monitoring is therefore necessary in any colony, inbred or outbred, in which genotype is of importance.’
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Congenic, Coisogenic and Segregating Inbred Strainsn question. The resulting partially coisogenic strains, which differ at the differential locus and an associated segment of chromosome, are known as congenic strains. Congenic strains which differ at a histocompatibility locus have been called ‘congenic resistant’ strains, because they resist tissue and specific tumour transplants.
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Inbreeding and its Consequences, and the History of Inbred Strainsuture all research on mice should be carried out on inbred animals or on hybrid mice of known (genetically controlled) origin where the degree of biological variability has been carefully controlled.’
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Inbred Strains of Guinea-pigsst research workers. Ideally, in the future one or two centres throughout the world should each maintain half-adozen strains to ensure their future availability. The strains should also be characterised in more detail to provide additional background data for future research workers.
发表于 2025-3-28 03:48:27 | 显示全部楼层
Strategy in the Use of Inbred Strainsresents only a single genotype. Generalisations based on such material must be treated with great caution, although in-depth studies of a single strain may well generate a number of useful hypotheses that can be tested at a later date.
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