Titlebook: Inbred Strains in Biomedical Research; Michael F. W. Festing Textbook 1979Latest edition Michael F. W. Festing 1979 boundary element metho

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The Breeding and Maintenance of Inbred Strainsis chapter a recommended system will be described (based on that of Lane-Petter and Bloom, 1957) and the details will then be justified. Similar systems have been described by Green (1968) and Hansen .. (1973), and Falconer (1972) has considered some aspects of the problem.

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Stability of Strain Characteristics a well-known example, but behaviour, response to drugs, antigens, infection and many other characteristics vary between strains. The stability of these characteristics over long periods of time and in different environments therefore needs to be considered. Stability of strain characteristics depen

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Congenic, Coisogenic and Segregating Inbred Strains strains arise as a result of mutation within an inbred strain. Strains that approximate the coisogenic status can be developed by backcrossing a gene from a donor strain or stock into an inbred strain (the background strain or inbred partner), or by inbreeding with forced segregation at the locus i

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Strategy in the Use of Inbred Strainsptimum use of their valuable properties and avoiding the pitfalls that their misuse can present. It is important to remember that an inbred strain represents only a single genotype. Generalisations based on such material must be treated with great caution, although in-depth studies of a single strai

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Inbred Strains of Ratsgh it is heavily dependent on previous listings (Festing and Staats, 1973). In contrast with previous listings, an attempt has been made to cite the original reference for any given strain characteristic. Particular attention has also been given to studies involving several inbred strains and, where