Titlebook: In Vivo Reprogramming in Regenerative Medicine; Açelya Yilmazer Book 2017 Springer International Publishing AG 2017 Brain Repair.Cardiomyo

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978-3-319-88090-7Springer International Publishing AG 2017

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Introduction to In Vivo Cell Reprogramming Technology,der to restore the normal biological function. There has been significant improvements in the development of cell based therapies; however, current treatment strategies still suffer from some problems: the need for long . culture conditions, inefficient delivery of cells by scaffolds and low incorpo

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In Vivo Reprogramming for Regenerating Insulin-Secreting Cells,(T1D) results from destruction of insulin-secreting beta cells of the pancreas. Replenishing beta cells is an effective therapy for T1D. Many research efforts are underway to produce insulin-secreting cells using human embryonic stem cell differentiation or direct reprogramming of adult cells. In th

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Direct Reprogramming to Beta Cells,cose concentration. There are various possible ways this might be done, but this chapter will focus on the reprogramming of other cell types to beta cells mediated by the introduction of specific transcription factors. Most experiments have used the gene combination . and . (PNM) introduced to cells

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In Vivo Lineage Reprogramming of Fibroblasts to Cardiomyocytes for Heart Regeneration,pacity of cardiomyocytes after injury such as myocardial infarction. The advances of cellular reprogramming that leveraged knowledge from decades of research in developmental biology provide a promising approach to convert cell fate and generate reprogrammed cells in situ. Production of induced card

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In Vivo Cell Reprogramming to Pluripotency,, in vitro, the differentiated status of a variety of cell types back to pluripotency, giving rise to so-called induced pluripotent stem (iPS) cells. Ten years after this revolutionary discovery, attempts to induce pluripotency have not been limited to the culture dish. Some studies have interrogate

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In Vivo Reprogramming Towards Pluripotency for Tissue Repair and Regeneration,ssion) has been proposed as a new therapeutic avenue to tackle conditions in which the regenerative capabilities of the organism cannot cope with the magnitude of cell loss. Thanks to their capacity to proliferate and to re-differentiate into mature phenotypes, in vivo reprogrammed cells could act a