Titlebook: In Vitro Differentiation of T-Cells; Methods and Protocol Shin Kaneko Book 2019 Springer Science+Business Media, LLC, part of Springer Natu

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Generation of Hematopoietic Stem and Progenitor Cells from Human Pluripotent Stem Cells,stained self-renewal and multilineage differentiation capacities upon transplantation. In this review, recent promising advances in the efforts to generate HSCs and hematopoietic progenitors from human PSCs in vitro and in vivo or from somatic cells are discussed.

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In Vitro Differentiation of T Cells: From Human Embryonic Stem Cells and Induced Pluripotent Stem Com PSCs involves three steps: induction of PSCs to hematopoietic progenitor cells (HPCs), differentiation of HPCs into progenitor T cells, and maturation of progenitor T cells into mature T cells (CD8 single-positive (SP) or CD4 SP).

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,Differentiating CD8αβ T Cells from TCR-Transduced iPSCs for Cancer Immunotherapy,ed iPSCs (TCR-iPSCs). These T cells express monoclonal expression of the transduced TCR. Generating CD8αβ CTLs from TCR-iPSC could contribute to safe and effective allogeneic regenerative T cell immunotherapies.

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In Vitro Differentiation of T Cell: From CAR-Modified T-iPSC, this approach. CAR-engineered iPSCs are demonstrated to give rise to CAR-engineered T cell and exert their effector function. In this section, we describe the method to generate CAR-engineered iPSCs and differentiate them into T cells.

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1064-3745 expertsThis book explores the vital importance of T-cell differentiation in areas as wide-ranging as pathological analysis, drug development, and cell therapy of human T-cells. Focusing on human embryonic stem cells and human induced pluripotent stem cells, the chapters explore a variety of .in vit