Titlebook: Immunotherapy for Gastrointestinal Malignancies; Ramakrishna Vadde,Ganji Purnachandra Nagaraju Book 2020 The Editor(s) (if applicable) and

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Gayatri Gouda,Manoj Kumar Gupta,Ravindra Donde,Lambodar Behera,Ramakrishna Vaddel mechanism of hemoglobin has come from the study of abnormal human hemoglobins. Now that the genes for the α and . chains of hemoglobin and for the single chain of myoglobin have been cloned in . directed mutagenesis has provided new tools for probing the reactions of these proteins with ligands. F

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Bindu Prasuna Aloor,Senthilkumar Rajagopalver, despite much speculation in the literature, the mechanism of captopril’s blood pressure lowering effect has not been fully clarified (3). It is attractive to opt for simplicity and to accept that the drug exerts its effect solely through prevention of angiotensin II formation. Indeed the fall i

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Henu Kumar Verma,Neha Merchant,L. V. K. S. Bhaskarver, despite much speculation in the literature, the mechanism of captopril’s blood pressure lowering effect has not been fully clarified (3). It is attractive to opt for simplicity and to accept that the drug exerts its effect solely through prevention of angiotensin II formation. Indeed the fall i

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Tumor Heterogeneity: Challenges and Perspectives for Gastrointestinal Cancer Therapy,uencing approaches, for instance, single-cell RNA sequencing, and models, for instance, the “Clonal evolution” model and “big bang” model, have been developed to date. However, the complete mechanism associated with tumor heterogeneity remains elusive to date. Authors believe that by integrating inf

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Immunocomposition of Gastrointestinal Tract of Gut,made up of a large population of scattered immune cells and organised lymphoid tissues termed the gut-associated lymphoid tissue (GALT). This book chapter provides an overview of the primary components of the human mucosal immune system and how the immune responses in the GI tract are coordinated an

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Immune Cell Therapy Against Gastrointestinal Tract Cancers,g the immune system of cancer patients. Recently, immune checkpoints approaches have also been employed in the treatment and prevention of cancer. However, various studies have reported that few of these therapies have side effects. Thus, these therapies must be employed with utter caution. Recently

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Immune Checkpoint Inhibitors in Gastrointestinal Malignancies,ally, cancer cells are recognized by patients own immune system as foreign and can be eliminated. But cancer cells escape the immune system by expressing the inhibitory immune checkpoint (IC) signal target receptor molecules for PD-1, CTLA4, A2AR, etc., and immune cells cannot recognize these cancer

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