Titlebook: Immunosenescence; Graham Pawelec Book 2007 Springer-Verlag New York 2007 Immunosenescence.age.aging.assessment.autoimmune disease.cancer.i

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collected in this volume therefore address not only the mechanisms responsible for immune ageing in humans but consider what might be accomplished to redress the erosion of immune competence with age..978-1-4419-2639-5978-0-387-76842-7

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Telomeres, Telomerase and CD28 in Human CD8 T-Cells: Effects on Immunity during Aging and HIV Infecell pool in humans. This chapter will focus on the complex relationship between telomeres, telomerase and the T-cell costimulatory receptor, CD28, in modulating the process of CD8 T-cell replicative senescence and the impact of this process on aging and HIV disease.

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scular disease plateaus at around 80 years of age in industrialised countries, but death due to infectious disease continues to increase up to 100 years of age and beyond. Understanding the reasons for age-associated alterations to protective immunity in the elderly would facilitate the development

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T-Cell Signalling, a Complex Process for T-Cell Activation Compromised with Aging: When Membrane Ra alterations in the activation process involving the TCR, CD28 and IL-2 receptor signalling cascades are crucial to understanding immunoseneescence. The putative reasons for this altered activation of T-cells with aging will be reviewed here, based on our own recent work and international collaborations.

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Immunosenescence, Thymic Involution and Autoimmunity, maintain a youthful immune system. In this review we examine some features of immunosenescence and the work undertaken, with particular interest to the role of the cytokine interleukin-7, to further our understanding of the relationship between ageing and development of autoimmunity.

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Role of Chemokines and Chemokine Receptors in Diseases of Ageing,s, osteoarthritis and Alzheimer’s disease) and to increased mortality risk. In this chapter, we will briefly review the properties of chemokines and their receptors and highlight the roles of these chemoattractants in the above selected diseases of ageing.

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Book 2007ntions to reconstitute appropriate immune function, increase responsiveness to vaccination and extend healthspan. The majority of the papers collected in this volume therefore address not only the mechanisms responsible for immune ageing in humans but consider what might be accomplished to redress the erosion of immune competence with age..