Titlebook: INCREaSE; Proceedings of the 1 António Mortal,Jaime Aníbal,Miguel Oliveira Conference proceedings 2018 Springer International Publishing AG

Trigger-Point

n of Oct-3/4 expression is correlated with neoplastic transformation and therapy resistance in patients with various cancers. In CRC, for instance, an increase of Oct-3/4 is associated with migration, liver metastasis, and poor survival. In addition, higher expression of Oct-3/4 in CSCs is associate

dissent

Isabela Battistello Espíndola,Celso Maran de Oliveiraar, physiological, and developmental processes have been observed in various diseases including cancers. These non-coding RNAs also play important roles in the regulation of CSC properties. Several non-coding RNAs that regulate CSC properties have been identified; therefore, a better understanding o

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Entrancing

José Viegas,Jean-Pierre Gonçalves,Luís Andrade Paiss. Auspicious outcomes have also been reported either by targeting pathways selectively operating in CSCs (e.g. Hedgehog, Wnt, Notch and FAK) or by using specific CSC cytotoxic agents. Other compounds are able to attenuate the unique stemness properties of CSCs by forcing cell differentiation, and t

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Fronika Claziena Agatha de Witr mass, open new questions on how GSCs modulate GBM aggressiveness and response to therapy. The definition of these tumor features will allow to setup innovative multimodal therapies able to target GBM cells at multiple levels. In this chapter, we will discuss the major advances in the study of GSCs

Jubilation

lymphoma

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借喻

cancer of young men. And of course, three decades later we all know the story of Lance Armstrong, one of the world’s most famous testicular cancer survivors. However, as the breast cancer activists reminded us in the early 1990s, there were still more American women dying each year from breast canc