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Titlebook: I Domain Integrins; Donald Gullberg Book 2014 The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature

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,α2β1 Integrin,logy and disease states mediated by this receptor in immunity, cancer, and development [., ., ., ., ., .]. The role of the α2β1 integrin in these multiple complex biologic processes will be discussed in the chapter.
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,Integrin α11β1: A Major Collagen Receptor on Fibroblastic Cells,r eruption. Separate studies have suggested reduced levels of IGF-1 in mice lacking α11. Analysis of lung cancer has identified α11β1 as a functional important collagen receptor on carcinoma associated fibroblasts (CAFs) and a number of disease models are awaiting analysis to see the importance of this collagen receptor in pathological models.
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Evolution of Integrin I Domains,bunits. The vWFA domain is not unique to the α subunit as it is an integral part of . integrin β subunits and many other proteins. The βI domain has always been a component of integrins but the αI domain makes its appearance relatively late, in early chordates, since it is found in tunicates and lat
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