Titlebook: Hypoxia and the Circulation; Robert C. Roach (Research Director),Peter D. Wagne Conference proceedings 2007 The Editor(s) (if applicable)

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Biventricular Function at High Altitude: Implications for Regulation of Stroke Volume in Chronic Hyme is associated with reduction in left ventricular dimensions and filling pressure. An obvious explanation for this is the reduction in plasma volume observed at high altitude, but this does not appear to be the whole story. Neither is left ventricular systolic function abnormal even at the summit

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Metabolic Consequences Of Intermittent Hypoxia, or Syndrome X. Insulin resistance is also the primary risk factor for the development of type 2 diabetes mellitus, which is currently reaching epidemic proportions by affecting more than 170 million people worldwide. A combination of environmental and genetic factors have led to a dramatic rise in

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Vascular Consequences of Intermittent Hypoxia,out the day. Animal models have shown that this hypertensive effect requires an intact sympathetic nervous system and an intact carotid chemoreceptor reflex. The reninangiotensin system contributes importantly to hypertension in this model, because renal nerve denervation, angiotensin II receptor bl

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,Epithelial Sodium Channels in the Adult Lung – Important Modulators of Pulmonary Health and Diseasepe II and possibly type I cells. The rate-limiting step in this process is the activity of the heterotrimeric apical membrane epithelial Na+ channel (ENaC). Pharmacologic inhibitors and genetic manipulations that disrupt Na+ transport result in fluid accumulation within the lung and failure of gas e

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