Titlebook: Hypoxia and Cancer; Biological Implicati Giovanni Melillo Book 2014 Springer Science+Business Media New York 2014 cancer.microenvironment.t

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https://doi.org/10.1007/978-3-0348-6639-2ncreasing number of novel agents that target the DDR have been described and some are already undergoing clinical testing. Evidence from preclinical studies suggests that the use of some of these agents would be effective at targeting tumor cells in hypoxic regions.

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Wie aus Begriffen Bilder werden,m hypoxic manipulation using techniques such as gene expression profiling and functional imaging in order to enrich trial populations with appropriate patients. The use of dynamic monitoring of changes in hypoxia occurring throughout treatment will be needed to exploit microenvironmental changes induced by therapy.

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Hypoxia and Breast Cancer Metastasisession through the transcriptional activation of target genes in BCCs, lymphatic vessels, blood vessels, and supporting stromal cells within the primary tumor. Finally, we discuss the pharmacological inhibition of HIFs as a novel therapeutic approach to block breast cancer metastasis and improve patient survival.

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Clinical Exploitation of Hypoxiam hypoxic manipulation using techniques such as gene expression profiling and functional imaging in order to enrich trial populations with appropriate patients. The use of dynamic monitoring of changes in hypoxia occurring throughout treatment will be needed to exploit microenvironmental changes induced by therapy.

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https://doi.org/10.1007/978-3-8274-2454-9umor gene expression revealed by the analysis of the transcriptome of the tumor mass provides a global view of the hypoxic status of the tissue. The global and analytic assessment of tumor hypoxia, revealed by the whole tumor mass or by its individual components, will be discussed with particular emphasis on tumor-infiltrating leukocytes.

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Hypoxia and Gene Expressionumor gene expression revealed by the analysis of the transcriptome of the tumor mass provides a global view of the hypoxic status of the tissue. The global and analytic assessment of tumor hypoxia, revealed by the whole tumor mass or by its individual components, will be discussed with particular emphasis on tumor-infiltrating leukocytes.

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Book 2014xia and/or anoxia) in tumor tissues. Intra-tumor hypoxia profoundly affects the biological behavior of cancer cells, which become resistant to conventional therapies and acquire a more invasive and metastatic phenotype. Hypoxia is a hallmark of the malignant phenotype and a key feature of the tumor