| 书目名称 | Hypoxia and Cancer |
| 副标题 | Biological Implicati |
| 编辑 | Giovanni Melillo |
| 视频video | |
| 概述 | Features ?comprehensive and systematic analysis of biological and therapeutic targets associated with intra-tumor hypoxia.Focuses on translational aspects associated with intra-tumor hypoxia.Explores |
| 丛书名称 | Cancer Drug Discovery and Development |
| 图书封面 |  |
| 描述 | The imbalance between rapidly proliferating tumor cells and inadequate and inefficient tumor vasculature leads to a decrease in oxygen levels (hypoxia and/or anoxia) in tumor tissues. Intra-tumor hypoxia profoundly affects the biological behavior of cancer cells, which become resistant to conventional therapies and acquire a more invasive and metastatic phenotype. Hypoxia is a hallmark of the malignant phenotype and a key feature of the tumor microenvironment. Hypoxia Inducible Factor 1 (HIF-1) is a master regulator of the transcriptional response to oxygen deprivation. HIF triggers the expression of genes whose products induce angiogenesis, decrease oxygen consumption, switch metabolism to glycolysis, maintain a stem cell phenotype and select for more invasive and metastatic cells. Therapeutic approaches targeting HIF, directly or downstream mediators of its transcriptional activity, are being developed. Intra-tumor hypoxia is a topic has been gaining scientific interest over the last few years for its wide involvement in many physiological and pathological processes. .This volume will cover the latest research and translational aspects associated with intra-tumor hypoxia, alon |
| 出版日期 | Book 2014 |
| 关键词 | cancer; microenvironment; tumor hypoxia |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-1-4614-9167-5 |
| isbn_softcover | 978-1-4939-5355-4 |
| isbn_ebook | 978-1-4614-9167-5Series ISSN 2196-9906 Series E-ISSN 2196-9914 |
| issn_series | 2196-9906 |
| copyright | Springer Science+Business Media New York 2014 |
发表于 2025-3-21 18:57:11
