Titlebook: Hypoxia and Cancer; Biological Implicati Giovanni Melillo Book 2014 Springer Science+Business Media New York 2014 cancer.microenvironment.t

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Hypoxia and Radiation Therapye of different approaches that can reduce or eliminate tumor hypoxia and improve radiation response. Several of these have been tested clinically and in particular in combination with radiotherapy targeting hypoxia has proven beneficial. In order to target hypoxia specifically, a range of clinically

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Prodrug Strategies for Targeting Tumour Hypoxiaentral roles in tumour progression and resistance to cytotoxic chemotherapy and radiotherapy. While many molecular targets may offer synthetic lethal interactions with hypoxia, the development of prodrugs that are activated to generate cytotoxins by one-electron (1e) reduction in hypoxic cells repre

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https://doi.org/10.1007/978-3-0348-6639-2of the tumor. Severe levels of hypoxia (< 0.1 % O.) have been found to induce a unique DNA damage response (DDR) that includes both ATR- and ATM-mediated signaling. The consequences of the hypoxia-induced DDR include p53-dependent apoptosis and maintenance of replication fork integrity. Interestingl

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Wie Unternehmen sich selbst erneuernork has provided support to the idea that noncoding RNAs (ncRNAs), and in particular microRNAs (miRNAs), may play important roles in the adaptive response to low oxygen in tumors. Specifically, all published studies agree that the induction of microRNA-210 (miR-210) is a consistent feature of the hy

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