Titlebook: Hyperglycemia, Diabetes and Vascular Disease; Neil Ruderman,Joseph Williamson,Michael Brownlee Book 1992 American Physiological Society 19

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Diabetes Mellitus and the Vascular Endothelium endothelium-derived factor(s), prostaglandins, and peptides, modulate the tone of vascular smooth muscle, prevent platelet aggregation and thrombosis in the blood vessel lumen, and may modulate vessel growth. It is well known that vasomotor, thrombotic, and growth control mechanisms are abnormal in

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Mobilization of Arachidonic Acid from Diacyl and Ether Phospholipids in Cultured Endothelial Cells culture of endothelial cells provides an important tissue model, pure in cell type and easily manipulated. Although tissue culture offers slight possibilities of mimicking the total diabetic milieu, specific conditions that arise in the course of diabetes can be reproduced in a controlled and isola

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Glycation and Autoxidation of Proteins in Aging and Diabetes and denaturation of proteins by glucose. These reactions are known collectively as the Maillard reaction (17,25,39), in honor of Louis Camille Maillard for his work during the early part of this century, or the browning reaction because of the characteristic brown and fluorescent products formed du

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Nonenzymatic Glycosylation of Macromolecules: Prospects for Pharmacologic Modulationrogression of retinopathy, nephropathy, and neuropathy correlate closely with the magnitude and duration of target tissue exposure to abnormally high levels of blood glucose. Data from ongoing prospective studies of selected diabetic populations also indicate a clear association with diabetic macrov

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