Titlebook: Hyperglycemia, Diabetes and Vascular Disease; Neil Ruderman,Joseph Williamson,Michael Brownlee Book 1992 American Physiological Society 19

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Diabetes Mellitus and the Vascular Endothelium function of the endothelium. Because these vasomotor abnormalities result from the abnormal release of substances from the endothelium that may play a role in thrombosis and growth, an understanding of their mechanism of action may provide new insights to the basis of vascular complications in diabetes mellitus.

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Mobilization of Arachidonic Acid from Diacyl and Ether Phospholipids in Cultured Endothelial Cellsted manner. In this chapter, the discussion focuses on studies undertaken to examine arachidonic acid metabolism in endothelial cells and the influence upon it by elevated glucose levels similar to those found in patients with diabetes.

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Nonenzymatic Glycosylation of Macromolecules: Prospects for Pharmacologic Modulationascular complications. Current evidence suggests that a particular diabetic individual’s clinical course is also influenced by genetic determinants of tissue susceptibility and independent accelerating factors such as hypertension.

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Effects of Nonenzymatic Glycation on Molecular Interactions of Basement Membrane Moleculesonents that are thought to be the building blocks for this structure. It should be emphasized that the current list of well-characterized basement membrane macromolecules is a partial one, and certainly other components will soon be added.

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Epidemiology of Hyperglycemia and Atherosclerosistes a continued high prevalence of diabetes, largely undetected, among the general population (2). Despite improved diagnostic methods and better treatment, physicians continue to encounter a high rate of atherosclerotic cardiovascular sequelae in their diabetic patients.

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vels of blood glucose produce metabolic and biochemical alteIt is estimated that 1-5% ofthe world‘s population is affected by some form of diabetes. Patients with these disorders are highly likely to develop microvas­ cular pathology in the retina and glomerulus and they are at a 2--6-fold greater r