Titlebook: Huntington’s Disease; Sophie V. Precious,Anne E. Rosser,Stephen B. Dunne Book 2018 Springer Science+Business Media, LLC, part of Springer

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,Murine Models of Huntington’s Disease for Evaluating Therapeutics,reviewed in this chapter. As new interventions and therapeutic approaches are evaluated and implemented, genetic mouse models will continue to be used with the hope of developing effective treatments for HD.

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1064-3745 actical insights from experts in the fieldThis detailed book provides a laboratory manual and guidebook for the selection, implementation, and interpretation of a wide range of techniques in contemporary use in leading laboratories engaged in Huntington’s disease (HD) research worldwide. Only by und

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,Assessing Mitochondrial Function in In Vitro and Ex Vivo Models of Huntington’s Disease,mitochondrial calcium handling, and levels of mitochondrial ROS. Here we focus on biological samples derived from HD . control cells and/or animal models, namely functional isolated brain mitochondria, an ex vivo animal model, and cultured cells, including cell lines and primary neural cultures, as in vitro models.

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,Mouse Models of Huntington’s Disease, disorder. Here we review the transgenic, knock-in mice commonly used to model HD, as well those that have been generated to study specific disease mechanisms. We then provide a brief overview of the importance of standardizing the use of HD mice and describe brief protocols used for genotyping the mouse models used within the Bates Laboratory.

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,Stereological Methods to Quantify Cell Loss in the Huntington’s Disease Human Brain,ternative when tissue availability is limited. Both methods use systematic random sampling (SRS) techniques to account for the inhomogeneous nature of biological tissue. Here we describe the criteria for a successful and accurate stereological study, using human brain tissue.

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