Titlebook: Huntington’s Disease; Sophie V. Precious,Anne E. Rosser,Stephen B. Dunne Book 2018 Springer Science+Business Media, LLC, part of Springer

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书目名称Huntington’s Disease影响因子(影响力)




书目名称Huntington’s Disease影响因子(影响力)学科排名




书目名称Huntington’s Disease网络公开度




书目名称Huntington’s Disease网络公开度学科排名




书目名称Huntington’s Disease被引频次




书目名称Huntington’s Disease被引频次学科排名




书目名称Huntington’s Disease年度引用




书目名称Huntington’s Disease年度引用学科排名




书目名称Huntington’s Disease读者反馈




书目名称Huntington’s Disease读者反馈学科排名

BARK

Biomarker

轻打

Cellular Models: HD Patient-Derived Pluripotent Stem Cells,ene. Traditionally, HD cellular models consisted of either patient cells not affected by disease or rodent neurons expressing expanded polyQ repeats in HTT. As these models can be limited in their disease manifestation or proper genetic context, respectively, human HD pluripotent stem cells (PSCs) a

经典

实现

Modicum

regale

,Automated Operant Assessments of Huntington’s Disease Mouse Models,the disease progression, prior to the onset of motor symptoms, and they are significantly burdensome to people who are affected by HD. In order to determine the suitability of mouse models of HD in recapitulating the human condition, these models must be behaviorally tested and characterized. Operan

思考

,Neurophysiological Assessment of Huntington’s Disease Model Mice, fatal neurological disorder caused by an expansion of CAG repeats in the . gene. Changes in neuronal activity often precede the behavioral manifestations of HD, therefore, understanding the electrophysiology of HD is critical for identifying potential prodromal markers and therapeutic targets. This

Fillet,Filet

,Murine Models of Huntington’s Disease for Evaluating Therapeutics,typically present later on in life, although juvenile cases do exist. The identification of the disease-causing mutation, a CAG triplet repeat expansion in the HTT gene, in 1993 generated numerous investigations into the cellular and molecular pathways underlying the disorder. HD mouse models have p