书目名称 | Human Neural Stem Cells |
副标题 | From Generation to D |
编辑 | Leonora Buzanska |
视频video | |
概述 | Summarizes the most recent advances in human neural stem cells (hNSC) research.Presents hNSC derivation methods.Discusses mechanisms underlying NSC in vitro fate decisions and their in vivo therapeuti |
丛书名称 | Results and Problems in Cell Differentiation |
图书封面 |  |
描述 | .This book summarizes early pioneering achievements in the field of human neural stem cell (hNSC) research and combines them with the latest advances in stem cell technology, including reprogramming and gene editing. The powerful potential of hNSC to generate and repair the developing and adult CNS has been confirmed by numerous experimental in vitro and in vivo studies. The book presents methods for hNSC derivation and discusses the mechanisms underlying NSC in vitro fate decisions and their in vivo therapeutic mode of action..The long-standing dogma that the human central nervous system (CNS) lacks the ability to regenerate was refuted at the end of the 20th century, when evidence of the presence of neurogenic zones in the adult human brain was found. These neurogenic zones are home to human neural stem cells (hNSCs), which are capable of self-renewing and differentiating into neurons, astrocytes and oligodendrocytes. NSCs isolated from human CNS have a number of clinical advantages, especially the innate potential to differentiate into functional neural cells. Nevertheless, their full clinical exploitation has been hindered by limited access to the tissue and low expansion poten |
出版日期 | Book 2018 |
关键词 | human neural stem cells; hNSC; hNSC derivation; hNSC differentiation; hNSC engineering; hNSC clinical app |
版次 | 1 |
doi | https://doi.org/10.1007/978-3-319-93485-3 |
isbn_softcover | 978-3-030-06671-0 |
isbn_ebook | 978-3-319-93485-3Series ISSN 0080-1844 Series E-ISSN 1861-0412 |
issn_series | 0080-1844 |
copyright | Springer International Publishing AG, part of Springer Nature 2018 |