Titlebook: Human Neural Stem Cells; From Generation to D Leonora Buzanska Book 2018 Springer International Publishing AG, part of Springer Nature 2018

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OATH

Derivation of Neural Stem Cells from the Developing and Adult Human Braintherapy. The clear advantage of these cells over the more commonly utilised embryonic and pluripotent stem cells is that they are already neurally committed. Of particular importance is the fact that these cells don’t require the same level of in vitro culture that can be cost and labour intensive.

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Human Somatic Stem Cell Neural Differentiation Potentialnd ability to undergo neural differentiation. The first group will represent afterbirth somatic tissues, which are perinatal stem cells including placental blood and tissue, amniotic fluid and tissue, and umbilical cord blood- and umbilical cord tissue-derived cells. The second group of cells discus

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Generation of Human Neural Stem Cells by Direct Phenotypic Conversionlogical diseases using hNSC. This chapter summarizes the latest research trends in and fields for application of patient-specific hNSC using direct phenotypic conversion technology. The aim of the study was to analyze the advantages and disadvantages of current technology and to suggest relevant dir

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Epigenetic Regulation of Human Neural Stem Cell Differentiationferentiation. It is becoming apparent that epigenetic mechanisms, such as DNA methylation, histone modifications, and noncoding RNA expression, are spatiotemporally regulated and that these intracellular programs, in concert with extracellular signals, ensure appropriate gene activation. Here we sum

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Induced Pluripotent Stem Cells Reveal Common Neurodevelopmental Genome Deprograming in Schizophreniams. The abnormal developmental trajectory of the brain is established during gestation, long before clinical manifestation of the disease. Over 200 genes and even greater numbers of single nucleotide polymorphisms and copy number variations have been linked with schizophrenia. . We propose that the

HUSH

Genome Editing in Human Neural Stem and Progenitor Cellsting technologies built upon designer nucleases, such as CRISPR/Cas9, have recently emerged. Parallel progress has been made in methodologies for the expansion and differentiation of human pluripotent and tissue stem cells. Together these innovations provide a remarkable new toolbox for human cellul

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Brain Organoids: Expanding Our Understanding of Human Development and Diseasell (iPSC) technology offer an unprecedented model for investigating human neurological diseases including autism and microcephaly. We describe the history and birth of organoids and their application, focusing on cerebral organoids derived from embryonic stem cells and iPSCs. We discuss new insights

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