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Titlebook: Host Defenses and Immunomodulation to Intracellular Pathogens; Toby K. Eisenstein (Professor of Microbiology and Book 1988 Springer Scien

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Genetic Basis of Host Resistance and Susceptibility to Intracellular Pathogens and in the endemic areas of the world. Although the influence of environmental factors must be considered in any explanation of such variability, it has recently become clear, mainly on the basis of studying experimental infections in inbred animals, that genetic factors play decisive role in indiv
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Recognition and Binding of Pathogenic Yeasts by Adhesion Molecules of Human Macrophages of infections are acquired by inhalation of spores or fragments of the mycelial phase that is present in contaminated soil. After lodging within the pulmonary alveoli, spores or mycelial fragments convert to the yeast form of Hc that causes all subseqent disease manifestations. During the initial p
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Fusion of Lysosomes with Phagosomes Containing ,: Use of Fluoresceinated Dextrann clearing these yeasts from the lung, the macrophages instead harbor the organism and promote the development of a severe pulmonary or disseminated disease. We now believe that the lack of an oxidative burst by macrophages which encounter . (2, 3) may permit the yeasts to enter host cells undamaged
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A Mutation in , That Enhances Resistance to Oxygen-Independent Antimicrobal Neutrophil Proteino believe that resistance to them in . is under the control of at laast two distinct genes or clusters of genes. We think the matter of importance for, although these bacteria can survive intracellularly in neutrophils, the basis for their capacity to survive is poorly understood. Perhaps enhanced u
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Interaction of , with Peritoneal Macrophages from Various Mouse Strainsig mononuclear phagocytes (1,2), and infections caused by these organisms appear to correlate with the host’s cellular immune system (3). In this regard, the importance of mononuclear phagocytes in legionellosis has been suggested by a number of investigators (4,5,6). Guinea pigs are susceptible to
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The Protective Role of T Cells in Immunity to Malariaausing malaria, a disease characterized by high morbidity and mortality worldwide. In an effort to develop an effective vaccine to combat this disease, research has focused primarily on extracellular stages of the parasite presumably because they should be more accessible to antibody-dependent resis
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