Titlebook: Histone Recognition; Ming-Ming Zhou Book 2015 Springer International Publishing Switzerland 2015 Chromatin.Control of gene expression.Epig

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David F. Tough,Inmaculada Rioja,Rab K. Prinjhay probabilistic methodology, it was a very natural idea for the French "Académie des Sciences" to propose a series of public lectures, accessible to an educated audience, to promote a wider understanding for some of the fundamental ideas, techniques and new tools of the financial industries...These

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Histone Recognition by WD40 Proteins,ecognition by this family is not achieved through a single conserved binding mechanism; instead, structural analysis has revealed a number of distinct binding modes. The WD40 repeat folds into a β-propeller structure that creates a versatile platform that can mediate simultaneous interactions with m

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Methyl-Lysine Recognition by Ankyrin-Repeat Proteins,ith the very same polypeptide that generates it seems essential for some G9a/GLP functions, but it is dispensable for others. We first consider the structure of ANKs, particularly to illustrate that different binding modes can exist on the same scaffold and to facilitate the search for other meK-bin

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Methylarginine Recognition by Tudor Domains,ransduction from the cell surface, through the cytoplasm and into the nucleus. Arginine methylation is just one of these PTMs, and it has been implicated in a number of cellular processes, including RNA processing, DNA repair, protein translation, and the regulation of gene expression. It is an abun

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Histone Recognition by Tandem Modules and Modulation by Multiple PTMs,eukaryotic cells at the chromatin level and directs the establishment and maintenance of particular cellular traits. Recent progress suggests that the “ON” or “OFF” states of chromatin are not simply determined by the readout of a single histone or epigenetic mark. In fact, histone modifications oft

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