Titlebook: Handbook of Sepsis; W. Joost Wiersinga,Christopher W. Seymour Book 2018 Springer International Publishing AG, part of Springer Nature 2018

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Sepsis Biomarkers also to provide an indication of severity and prognosis and of response to treatment. C-reactive protein and procalcitonin are the biomarkers that have been most widely studied in sepsis, but there are many other potential candidates, including CD64 expression, adrenomedullin, sTREM-1, and presepsi

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Fluids in Sepsisersial. While recent data have provided considerable insights, there remains uncertainty as to the type, rate and volume of fluid that should be administered. In addition, the appropriate balance between fluids and vasopressors to achieve adequate end-organ perfusion at various stages of the septic

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Antimicrobial Therapyted to prognosis. Several studies have shown that inappropriate antimicrobial therapy was associated to increased mortality. An appropriate empiric antibiotic therapy includes, not only the susceptibility of the potential pathogen(s) to the agent(s), but also a correct timing for administration and

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Sepsis in Low- and Middle-Income Countriespite current epidemiological data suggesting a huge global burden of sepsis, knowledge regarding the incidence, prevalence, and mortality rates of sepsis is scarce, especially in low- and middle-income countries, which comprise 85% of the world’s population and usually have higher mortality rates th