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Titlebook: Handbook of Anticancer Pharmacokinetics and Pharmacodynamics; Michelle A. Rudek,Cindy H. Chau,Howard L. McLeod Book 2014Latest edition Spr

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Image & Seismic Information Processing,ials. This chapter summarizes the basic theory and application of pharmacometric techniques. Examples of where such pharmacometric principles have been successfully employed in oncology drug development are presented.
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Donald E. Thomas,Philip R. Moorbyal to translating pharmacogenomics into clinical practice. This chapter highlights the advancements that have been made with key examples such as tamoxifen and CYP2D6, erlotinib and EGFR, vemurafenib and BRAF, and many others.
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,Verilog — A Tutorial Introduction,ental factors appear to influence the CYP3A enzymatic activity more than genetic status. The challenges have been made to control the phenotypic CYP3A4 activity and to reduce pharmacokinetic variability of the relevant drugs. However, the clinical advantages obtained from these efforts should be carefully evaluated in view of clinical practice.
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Pharmacometrics,ials. This chapter summarizes the basic theory and application of pharmacometric techniques. Examples of where such pharmacometric principles have been successfully employed in oncology drug development are presented.
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Pharmacogenomics and Cancer Therapy: Somatic and Germline Polymorphisms,al to translating pharmacogenomics into clinical practice. This chapter highlights the advancements that have been made with key examples such as tamoxifen and CYP2D6, erlotinib and EGFR, vemurafenib and BRAF, and many others.
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Cytochrome P450,ental factors appear to influence the CYP3A enzymatic activity more than genetic status. The challenges have been made to control the phenotypic CYP3A4 activity and to reduce pharmacokinetic variability of the relevant drugs. However, the clinical advantages obtained from these efforts should be carefully evaluated in view of clinical practice.
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