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Titlebook: Handbook of Anticancer Pharmacokinetics and Pharmacodynamics; Michelle A. Rudek,Cindy H. Chau,Howard L. McLeod Book 2014Latest edition Spr

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书目名称Handbook of Anticancer Pharmacokinetics and Pharmacodynamics
编辑Michelle A. Rudek,Cindy H. Chau,Howard L. McLeod
视频video
概述Provides a detailed step-by-step guide to the successful design and approval of anticancer drugs.Features updated research from 1st Edition and new, additional chapters.Explores a wide variety of issu
丛书名称Cancer Drug Discovery and Development
图书封面Titlebook: Handbook of Anticancer Pharmacokinetics and Pharmacodynamics;  Michelle A. Rudek,Cindy H. Chau,Howard L. McLeod Book 2014Latest edition Spr
描述.There are many steps on the road from discovery of an anticancer drug to securing its final approval by the Food and Drug Administration. In this thoroughly updated and expanded second edition of the .Handbook of Anticancer Pharmacokinetics and Pharmacodynamics., leading investigators synthesize an invaluable overview of the experimental and clinical processes of anticancer drug development, creating a single indispensable reference that covers all the steps from the identification of cancer-specific molecular targets to screening techniques and the development and validation of bioanalytical methods to clinical trial design and all phases of clinical trials. The authors have included new material on phase 0 trials in oncology, organ dysfunction trials, drug formulations and their impact on anticancer drug PK/PD including strategies to improve drug delivery, pharmacogenomics and cancer therapy, high throughput platforms in drug metabolism and transport pharmacogenetics, imaging in drug development and nanotechnology in cancer..Authoritative and up-to-date, .Handbook of Anticancer Pharmacokinetics and Pharmacodynamics, 2nd Edition. provides in one comprehensive and highly practical
出版日期Book 2014Latest edition
关键词Cancer; Pharmacodynamics; Pharmacogenetics; Pharmacokinetics; Pharmacology
版次2
doihttps://doi.org/10.1007/978-1-4614-9135-4
isbn_softcover978-1-4939-3898-8
isbn_ebook978-1-4614-9135-4Series ISSN 2196-9906 Series E-ISSN 2196-9914
issn_series 2196-9906
copyrightSpringer Science+Business Media New York 2014
The information of publication is updating

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Phase 0 Trials in Oncology,gent demonstrates a desirable pharmacokinetic/pharmacodynamic profile, traditional phase I safety and tolerability studies are conducted; otherwise, further clinical development of the agent is unlikely to be justified. This chapter summarizes the key differences between phase 0 and phase I clinical
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Protein Binding,es in which monitoring of unbound concentrations might be useful: (1) agents demonstrating protein concentration-dependent binding, (2) agents that bind irreversible or near covalently, (3) when formulation excipients modulate unbound drug levels, and (4) metabolically interconversible agents. While
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Handbook of Anticancer Pharmacokinetics and Pharmacodynamics
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The Vegetation and Physiography of Sumatraal and each has a role for specific drugs. However, no one method is a practical dose calculation strategy for many or all drugs. Neither body size nor fixed dosing alone can be used for currently available drugs. Conclusion: Dosing strategies for anticancer drugs should be individualized according
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https://doi.org/10.1007/978-94-015-8066-3gent demonstrates a desirable pharmacokinetic/pharmacodynamic profile, traditional phase I safety and tolerability studies are conducted; otherwise, further clinical development of the agent is unlikely to be justified. This chapter summarizes the key differences between phase 0 and phase I clinical
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