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well received. Moreover, now an opportunity is provided to correct the problems or limitations that existed in the first edition as well as to address recent developments in the field. Thus, we are grateful to our friends, colleagues, and students, as well as to the reviewers who have expressed the

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https://doi.org/10.1007/978-3-319-45735-2 the clinical application of peptide inhibitors, many strategies have been developed to constrain peptides in their bioactive conformation. In this report, we describe several classic methods used to constrain peptides into a fixed secondary structure which could significantly improve their biophysical properties.

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Chemical Synthesis of Oligosialic Acid by Using 5-,,4-,-Carbonyl-Protected Sialyl Donors,the C8 hydroxy group of sialic acid. Cyclic acetal protection of the 7,8 dihydroxy groups is effective for α-sialylation of galactoside at the three position. The sialyl phosphonate underwent chemoselective glycosylation of thiosialoside and would be effective for convergent synthesis of complex oligosaccharides.

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Miguel A. Lopez-Carmona,Ivan Marsa-Maestre,Enrique de la Hoz,Juan R. Velascoll or organelle. In many cases the level of mutant in an affected tissue correlates well with disease severity. Ideally, a screening test to detect a pathogenic point mutation should not only identify the presence or absence of a pathogenic mutation, but also quantitate the level of the mutation com

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Hardware Accelerators for Autonomous Vehicles,performances. For operations safety issues of AI accelerators, the hardware accelerators must ensure the achievement of requirements for functional safety and safety of the intended functionality (SOTIF), so it is mandatory to comply with international standards during the development process. Under

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6-DOF Industrial Manipulator Motion Planning Based on RRT-Connect Algorithm,her spezifische Wege, exemplarisch ankonkreten Unternehmensbeispielen oder branchenspezifischen Entwicklungspfaden, fokussieren sich auf neue Technologien oder erörtern Nachhaltigkeit. Verbunden sind sie durch das analytische Rahmenwerk der Fähigkeiten, die sie alle in Bezug auf die Zukunftsfähigkeit diskutiere978-3-662-64902-2

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Infektionen. Geographisch ist die Ätiologie vieler Krankheiten ganz gewiß sehr verschieden, und für Schleswig-Holstein muß ich ohne weiteres der Tuberkulose eine größere Bedeutung für viele Augenkrankheiten zusprechen als z. B. für Breslau, wo ich acht Jahre lang ein etwa gleichgroßes Krankenmaterial gesehen h

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Book 2021.Chapters in the first section cover neural networks involved in normal sleep processes, including dreams and memory. Also discussed are how these neural networks interact in various sleep stages and sleep disorders, such as sleep related movement disorders. The book‘s second section explores the pa

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Arbeits- und Dienstvertragsrechtaufwendig ist. Zum anderen zeigt die Theorie, dass es viel mehr Probleme gibt, die man . mit Rechnern lösen kann, als solche, die man lösen kann. Aber selbst unter Vernachlässigung dieser Schwierigkeiten bleibt die mechanische Problemlösung in hohem Maße komplex.