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楼主: indulge
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Mechanism of Action of GHRP-6 and Nonpeptidyl Growth Hormone Secretagoguesomatotropin release inhibiting factor (SRIF) (Scheme 11.1). The factor controlling the episodic nature of GH release is unknown but its effects are probably mediated by feedback loops involving the positive effector GHRH and the negative regulator SRIF (1). In 1984, Bowers and Momany and coworkers (
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Metabolic Regulation of Growth Hormone Secretagogue Gene Expressionultiple effects on cellular metabolism. Plasma GH levels vary widely at different times of the day and night, with profound influences of diet, exercise, sleep, and stress in a given individual. GH levels also differ with sex, age, and body habits, providing a challenge to those defining “normal” GH
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The Role of Growth Hormone Releasing Hormone (GHRH) and Growth Hormone (GH) in the Onset of Puberty d somatostatin. Areas of the hypothalamus responsible for the control of GH release are the somatostatin neuron-containing periventricular nucleus (PeV) (1–3) and the GHRH neuron-containing arcuate nucleus (4–6).
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Jean Claude Promè,Nathalie Demontchlin had shown that rats made obese by some (rather extensive) hypothalamic stereotaxic lesions had shorter long bones than controls and that these bones had narrower epiphyseal cartilages. It was to take 23 years eventually to validate the concept by the isolation, amino acid sequencing and reprod
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