Titlebook: Good Research Practice in Non-Clinical Pharmacology and Biomedicine; Anton Bespalov,Martin C. Michel,Thomas Steckler Book‘‘‘‘‘‘‘‘ 2020 The

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Learning from Principles of Evidence-Based Medicine to Optimize Nonclinical Research Practices,ns, and other efforts. Discussions of the low reproducibility and robustness of some of this research have led to myriad efforts to increase data quality and thus reliability. Across the scientific ecosystem, regardless of the extent of concerns, debate about solutions, and differences among goals a

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General Principles of Preclinical Study Design,However, evidence has shown that poor quality in the design and conduct of these studies has not only impeded clinical translation but also led to significant waste of valuable research resources. It is clear that experimental biases are related to the poor quality seen with preclinical studies. In

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Resolving the Tension Between Exploration and Confirmation in Preclinical Biomedical Research, not for confirmation, and confirmatory research is often stigmatized as unoriginal and as a consequence faces barriers to publication. As a result, the current biomedical literature is dominated by exploration, which to complicate matters further is often disguised as confirmation. Only recently sc

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Out of Control? Managing Baseline Variability in Experimental Studies with Control Groups,pected to have an effect (positive control). Although they usually give results we can anticipate, they are an essential component of all experiments, both in vitro and in vivo, and fulfil a number of important roles in any experimental design. Perhaps most importantly they help you understand the i

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Quality of Research Tools,amiliarity with existing knowledge, key relevant concepts remain unknown as activities start. This is often an accepted risk, mitigated by gaining understanding in real time as the project develops. Chemicals play a role in all biology studies conducted in the context of drug discovery, whether endo

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Genetic Background and Sex: Impact on Generalizability of Research Findings in Pharmacology Studies problems and employed to evaluate potential therapeutic treatments in drug discovery. While inbred strains demonstrate relatively reliable and predictable responses, using a single inbred strain alone or as a background to a mutation is analogous to running a clinical trial in a single individual a