Titlebook: Good Research Practice in Non-Clinical Pharmacology and Biomedicine; Anton Bespalov,Martin C. Michel,Thomas Steckler Book‘‘‘‘‘‘‘‘ 2020 The

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Building Robustness into Translational Research,al robustness for both ethical and economic reasons. Key findings confirmed in multiple species have a greater chance to also occur in humans. Given the heterogeneity of patient populations, preclinical studies or at least programs comprising multiple studies need to reflect such heterogeneity, e.g.

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A Reckless Guide to P-values,cal evidence is embodied in . data and concerns the hypotheses of interest for . experiment, whereas the global error rate is a property of the statistical analysis and sampling procedure. It is shown using simple examples that local evidence and global error rates can be, and should be, considered

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Electronic Lab Notebooks and Experimental Design Assistants,lab notebook (pLN) has been employed for documentation of experimental procedures, but over the course of the last decades, the introduction of electronic tools has changed the research landscape and the way that work is performed. Nowadays, almost all data acquisition, analysis, presentation and ar

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Data Storage,chapter follows the life cycle of research data, by considering aspects ranging from storage and preservation to sharing and legal factors. While it provides a wide overview of the current ecosystem, it also pinpoints the elements comprising the modern research sharing practices such as metadata cre

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Design of Meta-Analysis Studies,ts and a prediction of the extent to which the findings might hold true under different experimental or real-world conditions. In some situations, the certainty and precision obtained from a single study are sufficient reliably to inform future research decisions. However, in other situations greate

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,Publishers’ Responsibilities in Promoting Data Quality and Reproducibility,e achieved by publishers in six key areas: (1) understanding researchers’ problems and motivations, by conducting and responding to the findings of surveys; (2) raising awareness of issues and encouraging behavioural and cultural change, by introducing consistent journal policies on sharing research

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Good Research Practice: Lessons from Animal Care and Use,gal framework in many geographical areas that researchers must comply with, and professional organizations continuously develop recommendations on specific areas of laboratory animal science. Scientific evidence demonstrates that many aspects of animal care and use which are beyond the legal require