Titlebook: Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins; Raphael Enoque Ferraz de Paiva Book 2018 Sp

plasma-cells

Basal-Ganglia

举止粗野的人

Irksome

Au(I)-Phosphine Series Designectrophiles, and we demonstrate that chemoselective auration is useful for probing the nucleocapsid topography. We also examined for comparison the “standard” gold-phosphine compound auranofin which contains a thiosugar co-ligand.

Engulf

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Book 2018plores gold(I)-phosphine, gold(III) complexes with N^N and C^N donors as inhibitors of the HIV-1 nucleocapsid protein (NCp7), in comparison to the human transcription factor Sp1. To determine the coordination sphere of the gold adducts formed by interaction with ZnFs, two innovative approaches are u

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胎儿

https://doi.org/10.1007/978-3-540-85849-2exes with ZnFs by monitoring the Au L3-edge and also the Zn K-edge. Furthermore, given the unique stability and reactivity of the Au(C^N) coordination motif discussed in Part II—Chap. ., the interaction of the compound [Au(bnpy)Cl2] with ZnFs was also studied by XAS.

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Probing the Protein: Ion Mobility Spectrometryed with collision induced dissociation (CID). This approach allowed inequivocal elucidation of specific binding sites and modes of gold-modified NCp7 (ZnF2) and Sp1 (ZnF3). While linear Cys-Au-Cys is indicated for NCp7 (ZnF2), a Cys-Au-His mode is indicated for the Sp1 (ZnF3) case.

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“Dual-Probe” X-Ray Absorption Spectroscopyexes with ZnFs by monitoring the Au L3-edge and also the Zn K-edge. Furthermore, given the unique stability and reactivity of the Au(C^N) coordination motif discussed in Part II—Chap. ., the interaction of the compound [Au(bnpy)Cl2] with ZnFs was also studied by XAS.