| 书目名称 | Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins | | 编辑 | Raphael Enoque Ferraz de Paiva | | 视频video | | | 概述 | Nominated as an outstanding Ph.D. thesis by the University of Campinas, Brazil.Presents an innovative approach, using gold chemistry to target zinc finger proteins.Explores the use of Travelling-Wave | | 丛书名称 | Springer Theses | | 图书封面 |  | | 描述 | .This book examines Au (I, III) complexes that selectively attack and inhibit zinc finger proteins (ZnFs) for potential therapeutic use. The author explores gold(I)-phosphine, gold(III) complexes with N^N and C^N donors as inhibitors of the HIV-1 nucleocapsid protein (NCp7), in comparison to the human transcription factor Sp1. To determine the coordination sphere of the gold adducts formed by interaction with ZnFs, two innovative approaches are used, based on Travelling-Wave Ion Mobility coupled with Mass Spectrometry (TWIM-MS), and X-ray Absorption Spectroscopy. Both approaches are proven to yield valuable structural information regarding the coordination sphere of gold in the adducts. In addition, the organometallic compound [Au (bnpy)Cl2] is evaluated. The system is shown to be capable of inhibiting ZnFs by means of C–S coupling.. | | 出版日期 | Book 2018 | | 关键词 | Gold Complexes; Nucleocapsid Protein NCp7; Human Trabscription Factor Protein 1 Sp1; Zinc Finger Protei | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-030-00853-6 | | isbn_softcover | 978-3-030-13150-0 | | isbn_ebook | 978-3-030-00853-6Series ISSN 2190-5053 Series E-ISSN 2190-5061 | | issn_series | 2190-5053 | | copyright | Springer Nature Switzerland AG 2018 |
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发表于 2025-3-21 18:02:07
