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Titlebook: Glutamine Metabolism in Mammalian Tissues; Dieter Häussinger,Helmut Sies Conference proceedings 1984 Springer- Verlag Berlin Heidelberg 19

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Cellular Distribution and Regulation of Glutamine Synthetase in Liverof nucleic acids and proteins. Consequently, glutamine synthetase is regulated by a complex control system, including repression/derepression of enzyme synthesis [1], cumulative feedback inhibition by metabolic effectors [2], and by metabolite controlled chemical interconversion of the enzyme [3,4].
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Liver Glutaminasemonstrated that the major part of the glutaminase activity was dependent on added phosphate and was located in the particulate fraction of the liver. Definitive evidence that glutaminase is a mitochondrial enzyme was first obtained by Guha [3]. Liver extracts also contain a phosphate-independent glu
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Renal Glutamine Metabolism and Hydrogen Ion Homeostasisand accelerates cellular autophagy. Most animals, including man, are faced with a surfeit of acid. The daily metabolic CO. production obligates the formation of some 15 mol of carbonic acid; normally expiration matches cellular CO. production so the H. homeostais is not threatened by this volatile a
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Effects of 2-Oxoglutarate and Glutamate on Glutamine Metabolism by Rat Kidney Mitochondriaacidosis. A perplexing problem has been the observation that despite an increase in renal ammoniagenesis from glutamine known to occur in acidosis in vivo, glutamine metabolism in vitro was depressed by acid pH [1–3], probably by inhibition of phosphate-dependent glutaminase [4]. Although glutamine
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