Titlebook: Glutamate and Addiction; Barbara H. Herman,Jerry Frankenheim,Steven R. Zuki Book 2002 Springer Science+Business Media New York 2002 Opioid

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Molecular Pharmacology and Physiology of Glutamate Receptorsr. Although clinical settings involving glutamate receptor modulators or antagonists usually involve stroke, acute brain injury, epilepsy, and neuropathic pain, both metabotropic and ionotropic classes of glutamate receptor also appear to play a role in addiction and cognition. For example, sensitiz

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Addiction and Glutamate-Dependent Plasticityen after abstinence is achieved, patients remain vulnerable to episodes of craving and relapse triggered by stimuli previously associated with the avail­ability of drug or the act of drug-taking .. This transition fits the definition of neuroplasticity, defined as the ability of the nervous system t