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Titlebook: Glutamate and Addiction; Barbara H. Herman,Jerry Frankenheim,Steven R. Zuki Book 2002 Springer Science+Business Media New York 2002 Opioid

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发表于 2025-3-21 18:14:11 | 显示全部楼层 |阅读模式
书目名称Glutamate and Addiction
编辑Barbara H. Herman,Jerry Frankenheim,Steven R. Zuki
视频video
概述Includes supplementary material:
丛书名称Contemporary Clinical Neuroscience
图书封面Titlebook: Glutamate and Addiction;  Barbara H. Herman,Jerry Frankenheim,Steven R. Zuki Book 2002 Springer Science+Business Media New York 2002 Opioid
描述In Glutamate and Addiction, world-renowned scientific experts critically review all of the evidence for the role of glutamatergic systems in opiate, stimulant, and alcohol addiction. Using a variety of pharmacological, biochemical, genetic, and brain imaging techniques, these investigators show precisely how glutamate affects such addictions and how modifying certain elements of the glutamatergic system appear to alleviate particular components of addiction. Their survey takes in both clinical approaches using medications that influence glutamate and cutting-edge preclinical approaches that manipulate specific subtypes of glutamate receptors or specific substrates of the "glutamate cascade" to determine their roles in various addictive states.
出版日期Book 2002
关键词Opioid; amphetamine; cocaine; dopamine; drugs of abuse; imaging techniques; neurotoxicity; physiology
版次1
doihttps://doi.org/10.1007/978-1-59259-306-4
isbn_softcover978-1-61737-234-6
isbn_ebook978-1-59259-306-4Series ISSN 2627-535X Series E-ISSN 2627-5341
issn_series 2627-535X
copyrightSpringer Science+Business Media New York 2002
The information of publication is updating

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Glutamate and Neurotoxicitycell death, was proposed to play a role in many pathological conditions, in large part based on the observations that injection of glutamate agonists, notably kainate, could result in neuronal death and biochemical abnormalities resembling the pathology seen in disorders such as Huntington’s disease
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Role of Glutamate and Nitric Oxide in the Acquisition and Expression of Cocaine-Induced Conditioned ization has been the meso-accumbens dopamine system because it has been shown to be involved in mediating the motorie effects of a variety of drugs .. The principal findings do indeed support a role for the mesoaccumbens dopamine projections in the development and expression of behavioral sensitizat
发表于 2025-3-22 16:08:58 | 显示全部楼层
Interactions of Dopamine, Glutamate, and GABA Systems in Mediating Amphetamine- and Cocaine-Induced ffect and sensitiza­tion, involve, in part, different circuits, even though they undoubtedly share some neuroeffector sys­tems. Starting with these working hypotheses, we initiated a study some 12 years ago that was designed to identify specific neuroeffectors and discrete brain areas that mediate a
发表于 2025-3-22 17:02:16 | 显示全部楼层
Glutamate Cascade from Metabotropic Glutamate Receptors to Gene Expression in Striatal NeuronsluRs expressed in the . oocyte system, the eight subtypes are currently classified into three functional groups .. Activation of group I mGluRs (mG1uR1/5) increases phosphoinositide (PI) hydrolysis via stimulation of phospholipase C, resulting in the subsequent Ca. release from internal stores and p
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Roles of Glutamate, Nitric Oxide, Oxidative Stress, and Apoptosis in the Neurotoxicity of Methamphetible role of glutamate and of NO in the cascade that leads to methamphetamine (METH)-induced neuro-toxicity. Moreover, this chapter will review briefly recent data that provide conclusive evidence that METH can also cause cell death in various regions of the brain.
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Nitric Oxide-Dependent Processes in the Action of Psychostimulantsmodulates the release of various neurotransmitters such as dopamine, gultamate, and norepinephrine (.). Thus, there is a reason to consider NO as a major neuromodulator of synaptic transmission in brain.
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