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Titlebook: Glucagon II; Pierre J. Lefebvre (Professor of Medicine, Guest P Book 1983 Springer-Verlag Berlin Heidelberg 1983 Glucagon

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Pharmacologic Compounds Affecting Glucagon Secretioneviews in . 1978; . and . 1979; see also Chap. 44). On the other hand, patients with glucagonoma often display an impressive clinical and biologic picture whose origin is best confirmed by its marked and rapid improvement by inhibitors of glucagon secretion (review in . and . 1981; see also Chap. 43
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Extrapancreatic Glucagon and Its Regulationin the mid-1970s, when three groups, working independently, almost simultaneously reported that the plasma of totally depancreatized dogs contained normal, or even increased, quantities of a material immunometrically indistinguishable from pancreatic glucagon by radioimmunoassays regarded as highly
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Glucagon and Starvationserving body protein. Initially, the predominant metabolic requirement is the maintenance of a continuing supply of blood glucose for utilization by obligate glucose-consuming tissues, especially brain. Because liver glycogen stores are rapidly exhausted, continuing hepatic glucose production to mai
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Glucagon and Pregnancyown to exert a diabetogenic stress on carbohydrate metabolism and second, the metabolic responses to starvation and food intake are characteristically modified by gestation. Evaluation of the possible contributory role of glucagon in bringing about these metabolic changes in pregnancy is obviously o
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Glucagon in the Fetus and the Newborncogenolytic and gluconeogenic effects on the liver, promotes hepatic glucose production, while insulin opposes both these actions and can cause a storage of glucose in hepatic glycogen under appropriate conditions (see Chaps. 14, 15, 16, and 37). Glucagon inhibits hepatic lipogenesis and triglycerid
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Glucagon as a Counterregulatory Hormone prevent the occurrence of hypoglycemia, but, should it occur, must then restore normoglycemia. The significance of these processes for homeostasis stems from the obligatory consumption of glucose by various tissues, the most important of which is the brain. In the postabsorptive state, utilization
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