Titlebook: Glial ⇔ Neuronal Signaling; Glenn I. Hatton,Vladimir Parpura Book 2004 Springer Science+Business Media New York 2004 biology.brain.cell.ce

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Gene function in glial-neuronal interactions, the gage for appropriate development and function of such a complex tissue. For this reason, the more we will understand the molecular and cellular bases of neuron-glia interactions, the more we will be able to unravel the complex processes underlying the differentiation, the function and the survi

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Structural association of glia with the various compartments of neurons,compartments, dedicated to one or more of these tasks. Generally, neurons are polarized in that one pole is optimized to receive information, and the other to transmit it to targets such as other neurons, muscles, glands, or to the circulating blood. The receptor pole may consist of a sensory proces

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Specialized channels in astrocytes,propagate electrical signals. In addition, astrocytes also contain more specialized channels that appear to engage in ion and water homeostasis in brain. Most notably, these include anion channels and water-permeable aquaporins. These channels are much less well understood than their voltage-gated c

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Glutamate uptake by astroglia,s essential that vesicular release result in fluctuations in the concentration of glutamate that are spatially and temporally constrained, to restrict signaling to defined contacts and to allow signaling to be sustained at high frequencies. Although dilution of glutamate in the extracellular space a

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pH regulation and acid/base-mediated transport in glial cells,tive cellular pH regulation, by secondary transporters carrying acid/base equivalents, and by metabolic processes. In particular, neurotransmission mediated by glutamate, γ-aminobutyric acid (GABA) or glycine as the transmitters, is associated with intra-and extracellular pH changes, which can be la

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