Titlebook: Germ Cell Tumours V; The Proceedings of t Patricia Harnden,Johnathan K. Joffe,William G. Jon Conference proceedings 2002 Springer-Verlag Lo

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The Genetics of Testicular Germ Cell Tumourstive risk is estimated to be 8–10 fold for brothers of cases and 4–6 fold for fathers and sons. This familial relative risk is considerably higher than for most common cancers suggesting that the contribution of genetic factors to TGCT may be relatively more important than for other cancers. However

Coronation

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Investigating Gain of 12p Material in Testicular Germ Cell Tumours and Its Apparent Absence in Carci] in around 80 per cent of cases. In some, high level gain or amplification corresponding to the sub-region of 12p at 12p11–12 has been found, indicating at least one region of 12p which harbours a gene or genes important in the development of TGCT.

Offbeat

Reactivity of Germ Cell Maturation Stage-specific Markers in Classical and Spermatocytic SeminomaAlthough spermatocytic seminoma might also originate from an embryonic germ cell, it retains the capacity to undergo further maturation, including partial meiosis. Moreover, we identified immunohistochemical markers helpful in the diagnosis of spermatocytic seminomas.

Serenity

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RT-PCR for AFP, HCG, GCAP and PDGF-1 To Detect Circulating Tumour Cells in Testicular Germ Cell Tumoitoneal lymph node status. Serum tumour markers are positive in only about 60 per cent of all patients and imaging modalities such as CT scan or MRI have a false negative rate of 25 per cent and a false positive rate of up to 10 per cent [1] and markers such as Ki-67, PCNA, p53, Bcl-2, E-cadherin an

Processes

The Prognostic Significance of Tumour Infiltrating Lymphocyte Count in Stage I Testicular Seminoma Mes, consistent with the concept that an active host immune response may inhibit tumor progression. Testicular seminoma is typically associated with a lymphocytic infiltrate, but although this infiltrate is notable for its intensity, the existence of a functional anti-tumour role has been questioned

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