Titlebook: Genomics in Endocrinology; DNA Microarray Analy Stuart Handwerger,Bruce Aronow Book 2008 Humana Press 2008 Abnormal endocrine cells.DNA.DNA

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Novel Molecular Signaling and Classification of Human Clinically Nonfunctioning Pituitary Adenomas I

Biomarker

Microarray-based Gene Expression Analysis of Endocrine Systems: Principles of Experimental Design andigm shift in which medical genetics has moved from being a tool of the basic investigator to play a role in the mainstream of medical practice. Identification of genetic causal agents of common endocrine disorders, deciphering underlying molecular pathophysiology of known conditions, development of

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Gene Expression Profiling in Leiomyoma in Response to GnRH Therapy and TGF-βssion, as well as their profiles in smooth muscle cells isolated from these tissues in response to direct action of GnRHa. We shall also discuss the influence of transforming growth factor beta (TGF-β), a profibrotic cytokine, on leiomyoma and myometrial smooth muscle gene expression profile and the

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Gene Profiling Analysis of Androgen Receptor Mediated Function of the underlying mechanisms that govern the AR function in these physiological and pathophysiological conditions. The aim of this chapter is to summarize the recent advances using genomics to study the role of androgens in developmental and reproductive processes, AIS, Kennedy’s disease, and prost

FEAS

Interrogating Estrogen Receptor α Signaling in Breast Cancer by Chromatin Immunoprecipitation Microaners (FoxA1 and c-MYC) are being uncovered that play critical roles in ERα -mediated transcription. Based on these findings, a model is constructed to show the complex network of ERα signaling. These new insights will support the development of more precise therapeutic regimen for breast cancer trea

沙发

Gene Expression Analysis of the Adrenal Cortex in Health and Disease that will be quickly outdated. However, there are a limited number of such studies of the adrenal cortex, and their results are surprisingly reproducible. This chapter summarizes all that has been published so far on this subject and points out the most important genes and molecular pathways that h

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Gene Expression Studies of Prostate Hyperplasia in Prolactin Transgenic Miceon of secretory material is also a major characteristic. By using cDNA microarray analysis we have obtained interesting insights into the molecular mechanisms involved in the prostate hyperplasia. Of particular interest is the significance of reduced apoptosis for the development/progression of the