Titlebook: Genomics in Endocrinology; DNA Microarray Analy Stuart Handwerger,Bruce Aronow Book 2008 Humana Press 2008 Abnormal endocrine cells.DNA.DNA

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digm shift in which medical genetics has moved from being a tool of the basic investigator to play a role in the mainstream of medical practice. Identification of genetic causal agents of common endocrine disorders, deciphering underlying molecular pathophysiology of known conditions, development of

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https://doi.org/10.1057/9780230373983the expression of IGF-I and the ALS of the IGFBP3 binding protein which in turn mediate many of the GH actions in extra hepatic tissues. STAT5b and presumably the members of the nuclear receptor family under GH control also influence genes involve in xenobiotic metabolism. GH actions in liver lead t

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Reference work 2023Latest edition that will be quickly outdated. However, there are a limited number of such studies of the adrenal cortex, and their results are surprisingly reproducible. This chapter summarizes all that has been published so far on this subject and points out the most important genes and molecular pathways that h

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Regularization and Incoherence,time point microarray experiments are effective in identifying genes regulated by a given treatment, e.g., direct target genes of a hormone treatment. However, because molecular pathways are dynamic processes that take place over time, single time point microarray experiments may not allow us to ide

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https://doi.org/10.1007/978-1-4757-2321-2on of secretory material is also a major characteristic. By using cDNA microarray analysis we have obtained interesting insights into the molecular mechanisms involved in the prostate hyperplasia. Of particular interest is the significance of reduced apoptosis for the development/progression of the

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le that cells, tissues, and perturbations applied to them can be characterized on the basis of their relative expression of genes and transcripts. Different biological states, cell types, and influences can be distinguished based on transcriptional profiles and the change in the relative levels of d