Titlebook: Genomics and Pharmacogenomics in Anticancer Drug Development and Clinical Response; Federico Innocenti Book 2009 Humana Press 2009 DNA.Dro

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https://doi.org/10.1007/978-3-540-72323-3c cancers. Rituximab, one of the commonly used monoclonal antibodies, was suggested to mediate its action mechanism via antibody-dependent cellular cytotoxicity (ADCC), complement-dependent cytotoxicity (CDC), or a direct pro-apoptotic effect. It has been proposed that the inter-individual variation

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Dialyse und Nephrologie für Pflegeberufeg to different cisplatin-based regimens. However, this clinical observation is spurious from the molecular point of view, bewcausse DNA repair genes involved in several pathways act as differential modulators of chemosensitivity. Low expression of ERCC1 or BRCA1 predicts higher sensitivity to cispla

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Rainer Nowack,Rainer Birck,Thomas Weinreichtive, head and neck, and breast cancers. The wide inter-patient variability observed in the pharmacokinetic profiles of these drugs is mainly caused by the erratic activity of dihydropyrimidine dehydrogenase (DPD), the enzyme responsible for fluoropyrimidines catabolism. Beside circadian variations,

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Methoden zur Planung und Kontrolle,gnostic and predictive factors in breast cancer mainly focus on the clinical–pathological parameters, which are unable to reveal the diverse molecular alterations of breast cancer and are imprecise in predicting breast cancer progression and clinical outcomes. In recent years, the advances in microa

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Toward the Realization of the Promise of Microarrays in Oncologytial, however, there have been few breakthroughs that can be directly attributed to microarray-based profiling. While many researchers now say that microarrays have been over-hyped, it is more likely that early experiments were simply conducted in a naïve manner. Many believe that as technology and