| 书目名称 | Genomics and Pharmacogenomics in Anticancer Drug Development and Clinical Response | | 编辑 | Federico Innocenti | | 视频video | | | 概述 | Comprehensive reference for researchers in the field of cancer pharmacogenomics and clinicians, from both academia and industry.Provides a collection of multi-disciplinary topics.Covers the most impor | | 丛书名称 | Cancer Drug Discovery and Development | | 图书封面 |  | | 描述 | Genomics and Pharmacogenomics in Anticancer Drug Development and Clinical Response provides the most comprehensive body of knowledge available on the role of genetic and genomic variation in the individualization of drug therapies in cancer patients. As a consequence of the intrinsic chromosomal and genetic instability of the tumor genome, it is generally believed that tailoring of chemotherapy in cancer - tients might be achieved by molecular analysis of patient tumor DNA. In addition, to reduce the toxicity risk of patients, the tumor DNA information should be in- grated with the available data on polymorphic drug-metabolizing enzyme and tra- porter genes mediating the exposure of patients to active drugs and/or their active metabolites. The chapters of this book clearly show how DNA information from both the host (germline) and the tumor should be taken into account for rational selection of drug therapies in cancer patients, an aspect that received little attention, despite its importance. The availability of new molecular approaches to the selection of drug therapy is an emerging need, because the traditional approach based on the evaluation of patient and tumor characteristic | | 出版日期 | Book 2009 | | 关键词 | DNA; Drogen; MicroRNAs; Microarrays; Oncology drug development; Pharmacogenomics; Single Nucleotide Polymo | | 版次 | 1 | | doi | https://doi.org/10.1007/978-1-60327-088-5 | | isbn_softcover | 978-1-61737-694-8 | | isbn_ebook | 978-1-60327-088-5Series ISSN 2196-9906 Series E-ISSN 2196-9914 | | issn_series | 2196-9906 | | copyright | Humana Press 2009 |
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发表于 2025-3-21 18:21:23
