Titlebook: Genomic Mosaicism in Neurons and Other Cell Types; José María Frade,Fred H. Gage Book 2017 Springer Science+Business Media LLC 2017 FISH.n

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Single-Cell CNV Detection in Human Neuronal Nucleis to isolate neuronal nuclei from human brain and identify megabase-scale copy number variants (CNVs) in single nuclei. The approach detailed herein includes use of CellRaft technology for single-nucleus isolation, the PicoPLEX approach to whole-genome amplification and library preparation, and a po

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参考书目

BOGUS

Analysis of LINE-1 Retrotransposition in Neural Progenitor Cells and Neuronssuggested that L1 activity, termed as L1 retrotransposition, may occur in somatic cells such as neural progenitor cells (NPC) in higher rate than other non-brain tissues. Indeed, L1 retrotransposition has been found to be associated with several types of neurological disorders. Thus, L1 activity may

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Estimation of LINE-1 Copy Number in the Brain Tissue and Isolated Neuronal Nucleispersed element-1 (LINE-1) retrotranspositions are usually rare, the targeting of specific brain cell types in genomic analyses of these mutations is critical. We previously reported that isolated neuronal nuclei from the prefrontal cortex of patients with schizophrenia exhibit increased numbers of

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FLOUR

Single-Cell Whole Genome Amplification and Sequencing to Study Neuronal Mosaicism and Diversityus mechanisms including errors in DNA replication acquired throughout development and by the activity of endogenous retrotransposons. The study of retrotransposition in neuronal mosaicism may prove crucial to understanding the true complexity of normal and aberrant brain function. Specifically, nume

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FISH Analysis of Aging-Associated Aneuploidy in Neurons and Nonneuronal Brain Cellsated as a main causal factor in aging. The most severe form of genomic instability is whole chromosome instability (W-CIN), a state where dysfunction in chromosome segregation leads to whole chromosomes gains and losses. Aneuploidy is commonly linked to pathological states. It is a hallmark of spont

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