Titlebook: Genomic Instability and Cancer Metastasis; Mechanisms, Emerging Chris Maxwell,Cal Roskelley Book 2015 Springer International Publishing Swi

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Knochen- und Gelenkkrankheiten,cal forces or defects in mechanosensors can result in misregulation of signaling pathways inside the cell, and ultimately lead to malignancy. Here, we discuss the ways in which physical attributes of the tumor microenvironment can promote metastasis and genomic instability, two hallmark features of cancer.

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1568-2102 ular and tissue phenotypes.Reviews emerging themes and highlMetastasis is the primary cause of mortality associated with cancer, and tumor genomic heterogeneity is a likely source for the cells that support cancer progression, resistance to therapy, and disease relapse. This book connects cancer met

perpetual

Cancer Metastasis: Tracking and Attacking a Moving Target,ion and the challenge of aiming clinical therapies at a seemingly unpredictable moving target. From an evolutionary perspective, metastasis can be considered as a process during which novel cell populations are generated that can exploit the unique tissue environments they encounter at a secondary t

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Mathematical Modeling for DNA Repair, Carcinogenesis and Cancer Detection,age, the DNA double strand break (DSB), and how it relates to cancer. DSB sensor proteins in the nucleus detect DNA breaks within minutes following damage. These proteins are now routinely labeled by immunocytochemistry, and access to high throughput fluorescence microscopy and robotics open the doo

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Animal Models of Metastasis,e metastatic cascade are made up of interactions between metastatic tumour cells, the solid tumour microenvironment, host normal cells, and host tissue. While our understanding of tumour cell migration and invasion has been greatly improved using a variety of . cell culture systems, the inherent com

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Microenvironmental Control of Metastatic Progression,dent and some newly recruited, that are often activated due to factors released by the tumor cells themselves. These activated cells then release soluble factors that feed forward on the tumour cells in a symbiotic manner. Activated cells also alter the deposition and processing of extracellular mat