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Titlebook: Genomic Imprinting; Methods and Protocol Andrew Ward Book 2002 Humana Press 2002

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发表于 2025-3-21 18:35:48 | 显示全部楼层 |阅读模式
书目名称Genomic Imprinting
副标题Methods and Protocol
编辑Andrew Ward
视频video
概述Includes supplementary material:
丛书名称Methods in Molecular Biology
图书封面Titlebook: Genomic Imprinting; Methods and Protocol Andrew Ward Book 2002 Humana Press 2002
描述Genomic imprinting is the process by which gene activity is regulated according to parent of origin. Usually, this means that either the maternally inherited or the paternally inherited allele of a gene is expressed while the opposite allele is repressed. The phenomenon is largely restricted to mammals and flowering plants and was first recognized at the level of whole genomes. Nuclear transplantation experiments carried out in mice in the late 1970s established the non-equivalence of the maternal and paternal genomes in mammals, and a similar conclusion was drawn from studies of interploidy crosses of flowering plants that extend back to at least the 1930s. Further mouse genetic studies, involving animals carrying balanced translocations (reviewed in Chapter 3), indicated that imprinted genes were likely to be widely scattered and would form a minority within the mammalian genome. The first imprinted genes were identified in the early 1990s; over forty are now known in mammals and the list continues steadily to expand.
出版日期Book 2002
版次1
doihttps://doi.org/10.1385/1592592112
isbn_softcover978-1-61737-164-6
isbn_ebook978-1-59259-211-1Series ISSN 1064-3745 Series E-ISSN 1940-6029
issn_series 1064-3745
copyrightHumana Press 2002
The information of publication is updating

书目名称Genomic Imprinting影响因子(影响力)




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Balanced Translocations for the Analysis of Imprinted Regions of the Mouse Genome,osome homologs can be easily distinguished. The use of animals with uniparental duplications and deficiencies of imprinted regions of interest is one powerful approach. This material not only allows the successful analysis of the monoallelic expression and genome modifications associated with imprin
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Production of YAC Transgenic Mice by Pronuclear Injection, plasmid-based constructs (less than 20 kb) have been favored for a number of reasons, particularly the ease with which they can be manipulated and purified in large quantities. While this approach is powerful, there are some problems associated with the size of these transgenes. In particular, many
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